| Product Name | PD 150606 |
|---|---|
| Description | PD 150606 is a cell-permeable non-peptide calpain inhibitor with Ki values for ν and m-calpains of 0.21 and 0.37 μM. PD 150606 targets the calcium binding sites of calpain and possesses very high selectivity for calpains relative to other proteases, acting as a non-competitive inhibitor with regard to the substrate. |
| Synonyms | 179528-45-1, PD 150606, PI-110, calpain inhibitor |
| Molecular Weight | 306.12 Da |
| Target | Calcium sensitive proteases |
| Amino Acid Sequence | Z-3-4-Iodophenyl-2-mercapto-2-propenoic acid |
| Form | Off white solid |
| Purity | >95% (HPLC) |
| Cas Number | 179528-45-1 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687 PMID: 8692879Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177 PMID: 9399991Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311 PMID: 9989777 Related areasAll small molecules >All calcium sensitive protease modulators > |
| Supplier | Isca Biochemicals Limited |
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