| Product Name | PD-1/CD279 Monoclonal Antibody |
|---|---|
| Description | PDCD1 (Programmed Cell Death 1) is a cell surface membrane protein of the immunoglobulin superfamily. It is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.Diseases associated with PDCD1 include Systemic Lupus Erythematosus 2 and Multiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways are Innate Immune System and CD28 co-stimulation. Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. |
| Synonyms | Programmed cell death protein 1 ,Protein PD-1,hPD-1,CD antigen CD279 |
| Host | Mouse |
| Clone | AS1A13 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of PD-1/CD279 |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | Q15116 |
| Background | PDCD1 (Programmed Cell Death 1) is a cell surface membrane protein of the immunoglobulin superfamily. It is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.Diseases associated with PDCD1 include Systemic Lupus Erythematosus 2 and Multiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways are Innate Immune System and CD28 co-stimulation. Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. |
| Supplier | Elabscience |
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