| Product Name | Pep2-8 |
|---|---|
| Description |
Pep2-8 is a peptide from a phage library that was identified as the smallest proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitor) with a clearly defined mechanism of inhibition. Pep2-8 binds to PCSK9 with a KD of 0.7 μm but has no affinity for other proprotein convertases. Pep2-8 restores low density lipoprotein (LDL) receptor function and LDL uptake in PCSK9-treated HepG2 cells. |
| Synonyms | 1541011-97-5, Ac-TVFTSWEEYLDWV-NH2, Pep 2-8, Pep2-8 |
| Molecular Weight | 1715.88 Da |
| Target | Other proteases |
| Amino Acid Sequence | Ac-TVFTSWEEYLDWV-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1541011-97-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N-terminal Ac, C-terminal amide |
| References |
Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID: 24225950 Related areas All peptides >All other protease modulators > |
| Supplier | Isca Biochemicals Limited |
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