| Product Name | Pepstatin A |
|---|---|
| Description | Pepstatin A is an inhibitor of aspartyl peptidases. Pepstatin A is highly selective for proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B and does not inhibit thiol proteases, neutral proteases, or serine proteases. Pepstatin A also inhibits solubilized γ-secretase and retroviral proteases and has been used to characterize proteases from a number of sources. |
| Synonyms | 26305-03-3, PI-120, PI120 , Pepstatin A, and protease B, aspartyl peptidases, bovine chymosin, cathepsin D, pepsin, proteases, renin, retroviral proteases, γ-secretase |
| Molecular Weight | 685.89 Da |
| Target | Secretases,Other proteases |
| Amino Acid Sequence | VVA |
| Form | Freeze dried solid |
| Purity | >98% by HPLC |
| Cas Number | 26305-03-3 |
| Storage | Store dry, dark and frozen |
| Notes | Modifications: Val-1 =is N-terminal H-iso-Valeryl, Val-2 is Val-4-amino-3-hydroxy-6-methylheptanoyl, Alanine-3 is Ala-4-amino-3-hydroxy-6-methylheptanoic-acid |
| References |
Umezawa et al (1970) Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J. Antibiot. 23(5) 259 PMID: 4912600Sato et al (2007) Autophagy Is Activated in Colorectal Cancer Cells and Contributes to the Tolerance to Nutrient Deprivation. Cancer Res. 67(20) 9677 PMID: 17942897Kania et al (2010) Urinary proteases degrade albumin: implications for measurement of albuminuria in stored samples. Ann. Clin. Biochem. 47(2) 151 PMID: 20150213CHEBI - Pepstatin A Related areas All peptides >All other protease modulators > |
| Supplier | Isca Biochemicals Limited |
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