| Product Name | Pexiganan |
|---|---|
| Description |
Pexiganan (MSI 78) is a synthetic cationic peptide and an analogue of magainin 2, the host defence peptide isolated from the skin of the African frog Xenopus laevis. Pexiganan exhibits in vitro broad-spectrum antibacterial activity against many gram-positive and gram-negative, anaerobic and aerobic bacteria and is the first AMP developed into an antibacterial drug and the best-studied AMP to date for therapeutic purposes. Pexiganan shows a barrel-stave type mechanism of membrane disruption or channel formation and exerts its antibacterial effect by forming toroidal pores in bacterial membranes. |
| Synonyms | MSI 78 |
| Molecular Weight | 2477.21 Da |
| Target | Antibacterials |
| Amino Acid Sequence | GIGKFLKKAKKFGKAFVKILKK-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 147664-63-9 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Lamb and Wiseman (1998) Pexiganan acetate. Drugs 56(6) 1047 PMID: 9878992Gottler AND Ramamoorthy (2009) Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin. Biochim Biophys Acta. 1788(8):1680 PMID: 19010301RodrÃguez-Rojas et al (2020) Antimicrobial Peptide Induced-Stress Renders Staphylococcus aureus Susceptible to Toxic Nucleoside Analogs. Front Immunol. 11 1686 PMID: 33133056 Related areasAll antimicrobial peptides >All immunology categories > |
| Supplier | Isca Biochemicals Limited |
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