| Product Name | Phospho-MEK Kinase-1 (Thr1400) Polyclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP3K1 include 46Xy Sex Reversal 6 and 46 Xy Gonadal Dysgenesis. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K19. |
| Synonyms | MAP3K1, MAPKKK1, MEKK, MEKK1, Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1 |
| Host | Rabbit |
| Immunogen | Synthesized peptide derived from human MEK Kinase-1 around the phosphorylation site of Thr1400 |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Uniprot | Q13233 |
| Background | The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP3K1 include 46Xy Sex Reversal 6 and 46 Xy Gonadal Dysgenesis. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K19. |
| Supplier | Elabscience |
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