| Product Name | Phosphoramidon disodium |
|---|---|
| Description | Phosphoramidon is a metalloendopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Phosphoramidon is a potent inhibitor of thermolysin and other metallo-endopeptidases and also strongly inhibits mammalian enkephalinase but does not inhibit trypsin, papain, chymotrypsin or pepsin. Phosphoramidon has been used as a neprilysin (NEP) inhibitor to study amyloid beta (Aβ) uptake and degradation. |
| Synonyms | 119942-99-3, PI-130, PI130, Phosphoramidon, amyloid beta (A β) uptake, enkephalinase, metallo-endopeptidase, neprilysin, thermolysin |
| Molecular Weight | 587.47 Da |
| Target | Matrix metalloproteases,Other proteases |
| Amino Acid Sequence | LW |
| Form | Off white powder |
| Purity | >97% (HPLC) |
| Cas Number | 119942-99-3 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: N-(α-Rhamnopyranosyloxyhydroxyphosphinyl at N terminal |
| References |
Bao et al (2016) Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia. Protein Cell 7(6) 417 PMID: 27209302Goblirsch et al (2018) Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24. Acta. Crystallogr. D Struct. Biol. 74(Pt 8) 739 PMID: 30082509Li et al (2018) SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes. Neural Regen. Res. 13(11) 2005 PMID: 30233076 Related areasAll small molecules >All matrix metalloprotease modulators > |
| Supplier | Isca Biochemicals Limited |
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