| Product Name | PKA inhibitor (6-22) amide |
|---|---|
| Description | PKA inhibitor (6-22) amide, also known as PKI(6-22) amide, is an inhibitor of cAMP-dependent protein kinase (PKA). PKA Inhibitor (6-22) amide is derived from the active section of the heat-stable PKA inhibitor PKI, the endogenous PKA inhibitor protein, and is the shortest synthetic PKI peptide with high potency for PKA inhibition. PKA inhibitor (6-22) amide inhibition of PKA can decrease long-term potentiation (LTP) at hippocampal synapses and reverse morphine tolerance. |
| Synonyms | PKI(6-22) amide |
| Molecular Weight | 1868.1 Da |
| Target | Kinases |
| Amino Acid Sequence | TYADFIASGRTGRRNAI-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 121932-06-7 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. 264 8802 PMID: 2722799Glass et al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem. 264 14579 PMID: 2760075Otmakhova et al (2000) Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. 20 4446 PMID: 10844013 Related dataAll peptides >All kinase modulators >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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