| Product Name | PKI (14-22) amide, myristoylated |
|---|---|
| Description | PKI (14 - 22) amide, myristoylated, is a cell-permeable version of the protein kinase inhibitor (PKI) PKI (14-22) amide. When non-myristoylated, PKI (14-22) amide inhibits protein kinase A with a Ki of 36 nM and also inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1). Myristoylated peptides as a class may exhibit off-target activation of the funny current If in sinoatrial myocytes. |
| Synonyms | 201422-03-9, GRTGRRNAI, KS-110, KS110, Myr-GRTGRRNAI-NH2, PKI, PKI (14 - 22) amide, PKI (14-22) amide, cell-permeable, myristoylated, protein kinase A, protein kinase inhibitor |
| Molecular Weight | 1209.5 Da |
| Target | Kinases |
| Amino Acid Sequence | Myr-GRTGRRNAI-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 201422-03-9 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: Myristoyl at N terminal, amide at C terminal |
| References |
Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802 PMID: 2722799Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197 PMID: 12947318Liao et al (2011) Myristoylated peptides potentiate the funny current I(f) in sinoatrial myocytes. Channels 5(2) 115 doi:10.4161/chan.5.2.14195 Related areasAll cell penetrating peptides >All kinase modulators >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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