| Product Name | PKI (5-24) |
|---|---|
| Description | PKI (5-24), also known as PKA inhibitor (5-24), is a potent (Ki 2.3nM) competitive synthetic peptide inhibitor of cAMP-dependent protein kinase A (PKA) derived from the active domain of the naturally-occurring heat-stable inhibitor protein PKI. PKI (5-24) is only a very weak inhibitor of cGMP-dependent protein kinase (PKG). |
| Synonyms | PKA inhibitor (5-24) |
| Molecular Weight | 2222.7 Da |
| Target | Kinases |
| Amino Acid Sequence | TTYADFIASGRTGRRNAIHD |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 99534-03-9 |
| Storage | Store dark, frozen and desiccated |
| Notes | Modifications: None |
| References |
Cheng et al (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. 261 989 PMID: 3511044 Narayana et al (1997) Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry 36 4438 PMID: 9109651 Related data All peptides >All kinase modulators > |
| Supplier | Isca Biochemicals Limited |
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