| Product Name | PLAT, 311-562aa, Human, Baculovirus |
|---|---|
| Description | PLAT, also known as plasminogen activator, tissue type, is serine protease secreted by many cell types that participate in biological processes, such as tissue restructuring, cell migration, and tumor metastasis. It used to dissolve coronary fibrin clots that are the proximal causes of acute myocardial infarction. It plays a crucial role in regulating blood fibrinolysis, in maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. Recombinant human PLAT, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Plasminogen activator, tissue type, PLAT, T-PA, TPA |
| Host | Virus |
| Molecular Weight |
23.0kDa (208aa) 28-40KDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | ADPIKGGLFA DIASHPWQAA IFAKHRRSPG ERFLCGGILI SSCWILSAAH CFQERFPPHH LTVILGRTYR VVPGEEEQKF EVEKYIVHKE FDDDTYDNDI ALLQLKSDSS RCAQESSVVR TVCLPPADLQ LPDWTECELS GYGKHEALSP FYSERLKEAH VRLYPSSRCT SQHLLNRTVT DNMLCAGDTR SGGPQANLHD ACQGDSGGPL VCLNDGRMTL VGIISWGLGC GQKDVPGVYT KVTNYLDWIR DNMRPHHHHH H |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Orth K., et al. (1992) Proc Natl Acad Sci U S A. 89:7422-7426. Hu K., et al. (2008) Front Biosci. 13:5174-5186. |
| Background | PLAT, also known as plasminogen activator, tissue type, is serine protease secreted by many cell types that participate in biological processes, such as tissue restructuring, cell migration, and tumor metastasis. It used to dissolve coronary fibrin clots that are the proximal causes of acute myocardial infarction. It plays a crucial role in regulating blood fibrinolysis, in maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. Recombinant human PLAT, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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