| Product Name | Platelet glycoprotein 4, 30-439aa, Mouse, Baculovirus |
|---|---|
| Description | CD36, also known as platelet glycoprotein 4, is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands. It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues. It also plays a significant role in the initiation and pathogenesis of chronic inflammatory diseases such as Alzheimer s disease and atherosclerosis. It is an integral membrane protein primarily serving as receptors for thrombospondin and collagen and by the erythrocytes infected with the human malaria parasite. Recombinant mouse CD36, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Cd36, CD36 antigen, FAT, GPIV, Scarb3 |
| Host | Virus |
| Molecular Weight |
11.5kDa (103aa) 18-28KDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | ADPGDMLIEK TIKREVVLEE GTTAFKNWVK TGTTVYRQFW IFDVQNPDDV AKNSSKIKVK QRGPYTYRVR YLAKENITQD PEDHTVSFVQ PNGAIFEPSL SVGTEDDNFT VLNLAVAAAP HIYQNSFVQV VLNSLIKKSK SSMFQTRSLK ELLWGYKDPF LSLVPYPIST TVGVFYPYND TVDGVYKVFN GKDNISKVAI IESYKGKRNL SYWPSYCDMI NGTDAASFPP FVEKSRTLRF FSSDICRSIY AVFGSEIDLK GIPVYRFVLP ANAFASPLQN PDNHCFCTEK VISNNCTSYG VLDIGKCKEG KPVYISLPHF LHASPDVSEP IEGLHPNEDE HRTYLDVEPI TGFTLQFAKR LQVNILVKPA RKIEALKNLK RPYIVPILWL NETGTIGDEK AEMFKTQVTG KIKHHHHHH |
| Tag | His-tag |
| Reactivity | Mouse |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Febbraio M., et al. (2001) J. Clin. Invest. 108:785-791. Armstrong LC., et al. (2003) Matrix Biol. 22:63-71. |
| Background | CD36, also known as platelet glycoprotein 4, is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands. It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues. It also plays a significant role in the initiation and pathogenesis of chronic inflammatory diseases such as Alzheimer s disease and atherosclerosis. It is an integral membrane protein primarily serving as receptors for thrombospondin and collagen and by the erythrocytes infected with the human malaria parasite. Recombinant mouse CD36, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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