| Product Name | PLCG1 (Ab-771) Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to PLCG1 (Ab-771) |
| Synonyms | 1 phosphatidyl D myo inositol 4 5 bisphosphate antibody; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody; Inositoltrisphosphohydrolase antibody; Monophosphatidylinositol phosphodiesterase antibody; NCKAP3 antibody; Phosphatidylinositol phospholipase C antibody; Phosphoinositidase C antibody; Phosphoinositide phospholipase C antibody; Phosphoinositide phospholipase C-gamma-1 antibody; Phospholipase C 148 antibody; Phospholipase C gamma 1 antibody; Phospholipase C-gamma-1 antibody; Phospholipase C-II antibody; PLC gamma 1 antibody; PLC II antibody; PLC-148 antibody; PLC-gamma-1 antibody; PLC-II antibody; PLC1 antibody; PLC148 antibody; Plcg1 antibody; PLCG1_HUMAN antibody; PLCgamma1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized non-phosphopeptide derived from human PLCG1 around the phosphorylation site of tyrosine 771 (P-D-Y-G-A). |
| Isotype | IgG |
| Target | PLCG1 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P19174 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Denis Tvorogov, J. Cell Sci., Feb 2005; 118: 601 - 610. Brenda J. Irvin, Mol. Cell. Biol., Dec 2000; 20: 9149 - 9161. Benoit Poulin, J. Biol. Chem., Feb 2000; 275: 6411. Ichiro Nakamura, J. Cell Biol., Jan 2001; 152: 361. |
| Supplier | Cusabio |
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