| Product Name | PLP (139-151) |
|---|---|
| Description | PLP (139-151), or proteolipid protein (139-151) is a myelin proteolipid protein (PLP) fragment. PLP is one of the major protein constituents of myelin, along with myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP), which between them make up 15% - 25% of dry weight, the rest being mainly lipids. Myelin has an essential insulating role for nerves, allowing normal motor function, sensory function and cognition. Animals immunized with PLP (139-151) develop severe experimental allergic encephalomyelitis (EAE) and this model is widely used to study human multiple sclerosis (MS). |
| Synonyms | Proteolipid protein (139-151) |
| Molecular Weight | 1537.8 Da |
| Target | Epitopes |
| Amino Acid Sequence | HCLGKWLGHPDKF |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 131334-43-5 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523 PMID: 2465343Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology 59 305 PMID: 1716908Tigno-Aranjuez et al (2009) Encephalitogenicity of Complete Freund€™s Adjuvant Relative to CpG Is Linked to Induction of Th17 Cells. J. Immunol. 183(9) 5654 PMID: 19812193 Related areasAll myelin peptides >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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