| Product Name | PR 39 |
|---|---|
| Description | PR 39 is a 39 amino acid proline-rich cathelicidin host defence and immunomodulatory peptide isolated from porcine polymorphonuclear neutrophils. PR 39 plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, PR 39 is involved in wound healing and also stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα. |
| Synonyms | 139637-11-9, AM-110, AM110, H-RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2, PR 39 , PR39, RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2, angiogenesis, cathelicidin, immunomodulatory, wound healing |
| Molecular Weight | 4719.7 Da |
| Target | Proteasome,Antibacterials |
| Amino Acid Sequence | RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 139637-11-9 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Li et al (2000) PR39, a peptide regulator of angiogenesis. Nat.Med. 6 356 PMID: 10613823Gaczynska et al (2003) Proline and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry 42 8663 PMID: 12873125Veldhuizen et al (2014) Antimicrobial and immunomodulatory activities of PR-39 derived peptides. PLoS One 9(4) e95939 PMID: 24755622 Related areasAll antimicrobial peptides >All immunology categories >All proteasome modulators > |
| Supplier | Isca Biochemicals Limited |
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