PRL-3, 1-173aa, Human, Recombinant

Proteins, Recombinant
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Product Name PRL-3, 1-173aa, Human, Recombinant
Applications SDS-PAGE
Background Protein tyrosine phosphatase type IVA 3 (PRL-3), as known as PTP4A3, belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) that remove phosphate modifications from tyrosine residues on proteins. This protein enhances cell proliferation, cell motility and invasive activity. High levels of PRL-3 expression are associated with tumorigenesis and metastasis, thus it is overexpressed in metastatic colorectal, ovarian, liver and skin cancers. Recombinant human PRL-3, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Concentration 1 mg/ml (determined by Bradford assay)
Endotoxin Level < 1.0 EU per 1 microgram of protein (determined by LAL method )
Form Liquid, in 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT.
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 23.9 kDa (207aa), confirmed by MALDI-TOF.
NCBI Accession # NP_116000
Purity > 95% by SDS-PAGE
References Ooki A., et al. (2009). Oncol Rep. 21(6):1467-75
Wang Z., et al. (2009). Ann Surg Oncol. 16(1):208-19.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms PTP4A3, PRL3, Protein tyrosine phosphatase type IVA 3 Potentially prenylated protein tyrosine phosphatase, PRL 3, PRL R, PRLR, Protein tyrosine phosphatase 4a3, PTP 4A3, Protein Tyrosine Phosphatase Type IVA Member 3
Tag His-tag

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