| Product Name | PSMA Monoclonal Antibody |
|---|---|
| Description | PSMA is a type II transmembrane protein with a molecular weight of 110 kDa. Its gene is located on the short arm of chromosome 11q. PSMA is expressed in normal and neoplastic prostate epithelium, and also expressed in some other tissues, such as breast, duodenum and benign epithelial cells of kidney tissue. The expression of PSMA in prostate cancer is positively related to tumor grade and the presence of hormonal resistance. It has been reported that this protein can be expressed in new vessels of non-prostate cancer, and PSMA is considered as a marker for prostate cancer.Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Synonyms | Glutamate carboxypeptidase 2 ,Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII, Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSM,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase |
| Host | Mouse |
| Clone | 2A2 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of PSMA |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | Q04609 |
| Background | PSMA is a type II transmembrane protein with a molecular weight of 110 kDa. Its gene is located on the short arm of chromosome 11q. PSMA is expressed in normal and neoplastic prostate epithelium, and also expressed in some other tissues, such as breast, duodenum and benign epithelial cells of kidney tissue. The expression of PSMA in prostate cancer is positively related to tumor grade and the presence of hormonal resistance. It has been reported that this protein can be expressed in new vessels of non-prostate cancer, and PSMA is considered as a marker for prostate cancer.Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Supplier | Elabscience |
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