| Product Name | PTP4A1, 1-170aa, Human |
|---|---|
| Description | PTP4A1, also known as protein tyrosine phosphatase type IVA 1, is cell signaling molecule that plays regulatory roles in a variety of cellular processes. This protein is a unique nuclear PTP that is induced in regenerating liver and mitogen stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. Recombinant human PTP4A1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Synonyms | Protein tyrosine phosphatase type IVA 1, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX17C1 |
| Host | E. coli |
| Molecular Weight | 35.9 kDa (323aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl. |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Zeng Q., et al. (2000), J. Biol. Chem., 275: 21444-21452. Jeong D.G., et al. (2005). J. Mol. Biol., 345: 401-413. |
| Background | PTP4A1, also known as protein tyrosine phosphatase type IVA 1, is cell signaling molecule that plays regulatory roles in a variety of cellular processes. This protein is a unique nuclear PTP that is induced in regenerating liver and mitogen stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. Recombinant human PTP4A1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Supplier | ARP |
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