| Product Name | PUMA BH3 |
|---|---|
| Description |
PUMA BH3 is a sequence derived from the BH3 domain of the BH3-only protein PUMA (p53 up-regulated modulator of apoptosis]. PUMA, also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein and member of the Bcl-2 protein family. Bcl-2 family proteins regulate the mitochondrial apoptosis pathway by controlling mitochondrial outer membrane permeabilization. The BCL2 protein family is divided into three subfamilies: antiapoptotic BCL2 family proteins, including BCL2, BCLxL, and MCL1; proapoptotic multi-domain BCL2 family proteins, including BAK, BAX, and BOK, and proapoptotic BH3-only proteins, including BIM, PUMA, BID, BAD, NOXA, BMF, HRK, and BIK. PUMA acts as a key mediator of cytosolic proapoptotic p53 function by freeing cytosolic p53 from inactive complexes with BCL-xL |
| Synonyms | PUMA BH3 peptide |
| Molecular Weight | 3049.33 Da |
| Target | Protein-protein interactions |
| Amino Acid Sequence | EEQWAREIGAQLRRMADDLNAQYER |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Cartron et al (2004) The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA. Molecular Cell, 16(5) 807 PMID: 15574335Fisher et al (2008) Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. PNAS 105(51) 20327 PMID: 19074266Ye et al (2020) Characterization of an alternative BAK-binding site for BH3 peptides. Nat Commun 11 3301 PMID: 32620849 Related areas All peptides >All protein-protein interaction modulators >All regulated cell death research categories > |
| Supplier | Isca Biochemicals Limited |
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