| Product Name | Puromycin dihydrochloride |
|---|---|
| Description | Puromycin is a broad spectrum antibiotic and protein synthesis inhibitor produced by Streptomyces alboniger, active in both prokaryotes and eukaryotes. Puromycin is a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase (metallopeptidase). Puromycin is used in cell biology as a selective agent in cell culture systems. |
| Synonyms | 58-58-2, PI-160, PI160, Puromycin, aminopeptidase, antibiotic, cell biology, dipeptidyl-peptidase II, metallopeptidase, serine peptidase |
| Molecular Weight | 544.43 Da |
| Target | Other proteases |
| Amino Acid Sequence | 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride |
| Form | White solid |
| Purity | >98% (HPLC) |
| Cas Number | 58-58-2 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Azzam and Algranati (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes. Proc.Nat.Acad.Sci. 70 3866 PMID: 4590173Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction. Biochim.Biophys.Acta. 1150 89 PMID: 8334141Matsumoto and Saitoh H (2016) Puromycin induces SUMO and ubiquitin redistribution upon proteasome inhibition. Biochem. Biophys. Res. Comm. 476(3) 153 PMID: 27181354 Related areasAll small molecules >All antibacterial agents > |
| Supplier | Isca Biochemicals Limited |
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