| Product Name | pVHL Monoclonal Antibody |
|---|---|
| Description | VHL is a tumor suppressor gene. VHL disease and most patients of sporadic clear cell renal cell carcinoma often showed mutations of the gene. VHL is mainly used for the study of renal cell carcinoma and other malignant tumors.Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. |
| Synonyms | Von Hippel-Lindau disease tumor suppressor ,Protein G7,pVHL |
| Host | Mouse |
| Clone | PT0229 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of pVHL |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | P40337 |
| Background | VHL is a tumor suppressor gene. VHL disease and most patients of sporadic clear cell renal cell carcinoma often showed mutations of the gene. VHL is mainly used for the study of renal cell carcinoma and other malignant tumors.Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. |
| Supplier | Elabscience |
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