| Product Name | [Pyr1]-Apelin 13 |
|---|---|
| Description | [Pyr1]-Apelin 13 or [pGlu1]-apelin-13 is a highly potent pyroglutamyl form of apelin 13 which acts as the endogenous ligand for the apelin APJ receptor, with an EC50 of 0.37 nM. [Pyr1]-Apelin 13 is the predominant isoform detected in human heart and plasma and acts as a potent inotropic agent and vasodilator. |
| Synonyms | [Pyr1]-Apelin 13, [pGlu1]-apelin-13 |
| Molecular Weight | 1533.8 Da |
| Target | Apelin receptors |
| Amino Acid Sequence | XRPRLSHKGPMPF |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 217082-60-5 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: X is pGlu |
| References |
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471 PMID: 9792798Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. TiPS 36(9) 560 PMID: 26143239Guide to pharmacology - [Pyr1]-Apelin 13 Related areas All peptides >All apelin receptor modulators >All cardiovascular research categories > |
| Supplier | Isca Biochemicals Limited |
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