| Product Name | R 715 |
|---|---|
| Description | R 715 is a potent and selective bradykinin B1 receptor antagonist with a pA2 of 8.49 and no activity at B2 receptors. R 715 is metabolically stable and can reduce mechanical hypernociception in a mouse model of neuropathic pain. |
| Synonyms | pain, 185052-09-9, Ac-KRPPGFS-D βNal-I-OH, KRPPGFSXI, PN-070, PN070, R 715, R715, antagonist, bradykinin B1, hypernociception, neuropathy |
| Molecular Weight | 1140,4 |
| Target | Bradykinin receptors |
| Amino Acid Sequence | KRPPGFSXI |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 185052-09-9 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: Lys-1 is N-terminal Acetyl, X is DβNal |
| References |
Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension 28 833 PMID: 8901831Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856 PMID: 18337416Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136 PMID: 18311190 Related areas All peptides >All bradykinin receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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