| Product Name | R18 |
|---|---|
| Description | R18, also known as R18 peptide is an antagonist of 14.3.3 proteins, a family of conserved regulatory molecules that have the ability to bind a multitude of functionally diverse signaling proteins, with a KD of approximately 80 nM. R18 competitively inhibits 14.3.3 ligand interactions without requiring phosphorylation and can block the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. |
| Synonyms | R18 peptide |
| Molecular Weight | 2309.6 Da |
| Target | Protein-protein interactions,Kinases |
| Amino Acid Sequence | PHCVPRDLSWLDLEANMCLP |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 211364-78-2 |
| Storage | Store frozen and desiccated in the dark |
| Notes | Modifications: None |
| References |
Wang et al (1999) Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Biochemistry 38 12499 PMID: 10493820Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30 360 PMID: 12196095De Vries-van Leeuwen et al (2013) ERα activation is controlled by 14-3-3 proteins. Proc. Nat. Acad. Sci. 110(22) 8894 DOI: 10.1073/pnas.1220809110 Related areasAll peptides >All kinase modulators >All protein-protein interaction modulators > |
| Supplier | Isca Biochemicals Limited |
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