| Product Name | Rabbit anti-CD117, clone YR145 |
|---|---|
| Description | Rabbit anti-CD117, clone YR145 |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | YR145 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast; malignant melanoma, endodermal sinus tumor, and small cell carcinoma) but has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, and tumors of smooth muscle origin. |
| References | Sircar K, et al. AM J Surg Pathol 23(4):377-389,1999. Miettinen M et al. Am J Surg Pathol 24(2):211-222, 2000. Miettinen M. et al. Am J Surg Pathol 23(9): 1109-1118. Arber DA, Tamayo R, Weiss LM. Hum Pathol 1998 May: 29(5):498-504. Naeem M et al. Hum Pathol. 2002 Dec;33(12):1182-7 |
| Supplier | MONOSAN |
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