| Product Name | Rabbit anti-CD14, clone EPR3653 (Monoclonal) |
|---|---|
| Description | Rabbit anti-CD14, clone EPR3653 (Monoclonal) |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | EPR3653 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:50-1:200) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | CD14 is a 55kDa glycosyl-phosphatidylinositol-linked membrane protein, involved in endotoxin binding and recognition of apoptotic cells. CD14 is expressed on monocytes, macrophages, follicular dendritic cells, and granulocytes. Anti-CD14 can detect these cells, including monocyte-derived cells which are frequently increased in diffuse large B-cell lymphoma (DLBCL), as well as in neoplastic cells in acute myeloid leukemia with monocytic differentiation and chronic myelomonocytic leukemia. |
| References | Gregory CD, et al. Apoptosis. 1999; 4:11-20. Wright SD, et al. Science. 1990; 249: 1431-33. Marmey B, et al. Hum Pathol. 2006; 37:68-77. Smeltzer JP, et al. Clin Cancer Res. 2014; 20:2862-72. Rollins-Raval MA, et al. Histopathology. 2012; 60: 933-42 |
| Supplier | MONOSAN |
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