| Product Name | Rabbit anti-Human MUM1, clone MRQ-43 (Monoclonal) |
|---|---|
| Description | Rabbit anti-Human MUM1, clone MRQ-43 (Monoclonal) |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | MRQ-43 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:500) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes |
The antibody abels a 50kDa, multiple myeloma oncogen-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene. It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of terminal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas). Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma /leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma. |
| References | Grossman A, et al. Genomics. 1996; 37:229-33. Neresh KN. Haematologica. 2007; 92:267-8. Van Imhoff GW, et al. J Clin Oncol. 2006; 24:4135-42. Gualco G, et al. Appl Immunohistochem Mol Morphol. 2010; 18:301-10. Carbone A, et al. Br J Haematol. 2002; 117:366-72 |
| Supplier | MONOSAN |
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