| Product Name | Rabbit anti-P504s, clone 13H4 |
|---|---|
| Description | Rabbit anti-P504s, clone 13H4 |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | 13H4 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Alpha-Methylacyl-CoA Racemase (also known as AMACR or P504s) is an essential enzyme in the βoxidation of branched-chain fatty acids. AMACR over-expression has been demonstrated in several cancers including colorectal, prostate, ovarian, breast, bladder, lung, and renal cell carcinomas, lymphoma, and melanoma. Staining with the antibody to this enzyme has been useful in identifying prostate carcinoma and prostatic intraepithelial neoplasia, as well as atypical adenomatous hyperplasia in formalin-fixed paraffinized tissue in morphologically difficult cases. |
| References | Browne TJ et al. Hum Pathol. 2004 Dec;35(12):1462-8. Wu CL et al. Hum Pathol. 2004 Aug;35(8):1008-13. Evans AJ. J Clin Pthol. 2003 Dec;56(12):892-7. Beach R, Gown AM, et al. Am J Surg Pathol. 2002 Dec;26(12):1588-96. Jiang Z, Wu CL, et al. Am J Surg Pathol. 2002 Sep;26(9):1169-74 |
| Supplier | MONOSAN |
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