| Product Name | Rad17 derived peptide |
|---|---|
| Description |
Rad17 derived peptide is an ATR (ATM and Rad-3) related kinase substrate. ATR is a serine/threonine-specific protein kinase that along with ATM (ataxia telangiectasia mutated) is involved in sensing DNA damage and activating the DNA damage checkpoint, leading to cell cycle arrest. ATR inhibition sensitises cancer cells to DNA damaging agents, making it an attractive target for cancer therapy. Rad17 derived peptide is an effective substrate in ATR kinase assays and has been used succesfully to identify novel ATR kinase inhibitors. |
| Synonyms | ASELPASQPQPFSAKKK, Rad17 derived peptide, SP-050, SP050 |
| Molecular Weight | 1814.07 Da |
| Target | Kinases |
| Amino Acid Sequence | ASELPASQPQPFSAKKK |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Kim et al (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 274(53) 37538 PMID: 10608806Charrier et al (2011) Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 54(7) 2320 PMID: 21413798Kawasumi et al (2014) Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. 74(24) 7534 PMID: 25336189 Related areasAll kinase modulators >All substrate peptides >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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