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|Product Name||RAMP3, 24-118aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MRAGGCNETG MLERLPLCGK AFADMMGKVD VWKWCNLSEF IVYYESFTNC TEMEANVVGC YWPNPLAQGF ITGIHRQFFS NCTVDRVHLE DPPDEV|
|Background||RAMP3, also known as receptor activity modifying protein 3, is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). It is required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. Recombinant human RAMP3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT|
|Intended Use||For Research Use Only|
|Molecular Weight||26.5 kDa (245aa) confirmed by MALDI-TOF|
|NCBI Accession #||NP_005847|
|Purity||> 90% by SDS-PAGE|
|References||Kuwasako K. et al. (2008) Biochem Biophys Res Commun. 377:109-113.
Roh J. et al. (2004) J Biol Chem. 279:7264-7274
|Storage||Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.
Avoid repeated freezing and thawing cycles.
|Synonyms||Receptor activity modifying protein 3, Receptor (calcitonin) activity modifying protein 3|
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