| Product Name | Rat anti-Mouse Interleukin 6, clone MP5-32C11 (Monoclonal) |
|---|---|
| Description | Rat anti-Mouse Interleukin 6, clone MP5-32C11 (Monoclonal) |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | MP5-32C11 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG2a |
| Reactivity | Mouse |
| Applications | ELISA, FA |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration | 100 ug/ml |
| Storage | 2-8°C |
| Notes | The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNFalpha nor does it block human or rat IL-6 in proliferation assays using the KD83 cell line. MP5-32C11 inhibits mouse IL-6-induced proliferation of the NFS60 myelomonocytic cell line and KD83 plasmacytoma. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays a critical role in Bcell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of antibodyproducing hybridomas. |
| References | Takatsuki et al. J Immunol 1988;141:3072. McKenzie et al. J Immunol 1988;141:2907. van Snick et al. Annu Rev Immunol 1990;8:253. Heinrich et al. Biochem J 1990;265:621. Starnes et al. J Immunol 1990;145:4185 |
| Supplier | MONOSAN |
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