| Product Name | Rat anti-Mouse SIGN-R1, clone ER-TR9 (Monoclonal) |
|---|---|
| Description | Rat anti-Mouse SIGN-R1, clone ER-TR9 (Monoclonal) |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | ER-TR9 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgM |
| Reactivity | Mouse |
| Applications | IHC-Fr, FA, FC |
| Working Dilutions | ,, |
| Diluent Buffer | Sterile cell culture medium with 0.02% sodium azide |
| Concentration | 200 ug/ ml |
| Storage | 2-8°C |
| Notes | The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1,- a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C-terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood-borne microbial antigens. SIGN-R1 mediates the uptake of encapsulated microbes , particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody ER-TR9. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages. |
| References | Dijkstra; C; et al. Immunology 1985; 55: 23. Kretschmer, K, et al J Immunol 2003, 171: 6495. Kang; Y et al. PNAS 2004; 101: 215. Taylor P et al. J Immunol 2004; 172: 1157. Nagaoka K et al. Int Immunol 2005; 17: 827 |
| Supplier | MONOSAN |
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