Recombinant Human Corticotropin-releasing factor receptor 1 (CRHR1), partial
| Product Name | Recombinant Human Corticotropin-releasing factor receptor 1 (CRHR1), partial |
|---|---|
| Description | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal bryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Synonyms | Corticotropin-releasing hormone receptor 1 , CRH-R-1 , CRH-R1 |
| Host | Yeast |
| Molecular Weight | 13 |
| Amino Acid Sequence | ASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVI |
| Protein Length | Partial, 23-121aa |
| Tag | N-terminal 6xHis-tagged |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Tris-based buffer, 50% glycerol |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| References | Expression cloning of a human corticotropin-releasing-factor receptor.Chen R., Lewis K.A., Perrin M.H., Vale W.W.Proc. Natl. Acad. Sci. U.S.A. 90:8967-8971(1993) |
| Background | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal bryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Supplier | Cusabio |
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