Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn1a (PNTx4)
| Product Name | Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn1a (PNTx4) |
|---|---|
| Description | This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation. The toxin inhibits glutamate uptake from rat brain synaptosomes. It is highly toxic to house fly (Musca domestica), toxic to cockroach, but has no effect when intracerebroventricularly injected into mice. |
| Synonyms |
Insecticidal neurotoxin Tx4(6-1) Short name:PNTx4(6-1) |
| Host | Yeast |
| Molecular Weight | 7.3 |
| Amino Acid Sequence | CGDINAACKEDCDCCGYTTACDCYWSKSCKCREAAIVIYTAPKKKLTC |
| Protein Length | Full Length, 35-82aa |
| Tag | N-terminal 6xHis-tagged |
| Reactivity | Spider |
| Applications | SDS-PAGE |
| Form | Liquid, in Tris-based buffer, 50% glycerol |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| References | "Molecular cloning of cDNAs encoding insecticidal neurotoxic peptides from the spider Phoneutria nigriventer."Penaforte C.L., Prado V.F., Prado M.A.M., Romano-Silva M.A., Guimaraes P.E.M., De Marco L., Gomez M.V., Kalapothakis E.Toxicon 38:1443-1449(2000) |
| Background | This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation. The toxin inhibits glutamate uptake from rat brain synaptosomes. It is highly toxic to house fly (Musca domestica), toxic to cockroach, but has no effect when intracerebroventricularly injected into mice. |
| Supplier | Cusabio |
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