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|Product Name||RGS2, 1-211aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T|
|Background||RGS2, also known as G0S8, is a RGS family member and regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Recombinant human RGS2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 30% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||28.0 kDa (256aa) confirmed by MALDI-TOF|
|NCBI Accession #||NP_002914|
|Purity||> 90% by SDS-PAGE|
|References||Tang KM., et al. (2003) Nat Med. 9(12):1506-12.
Santos de Araujo RM., et al. (2007) Cell Biochem Funct. 25(6):753-8.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Regulator of G-protein signaling 2 24kDa, G0S8|
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