| Product Name | RNF4 Antibody, Biotin conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against RNF4 conjugated to Biotin. |
| Synonyms | E3 ubiquitin ligase RNF4 antibody; E3 ubiquitin protein ligase RNF4 antibody; Protein SNURF antibody; RES4 26 antibody; RING finger protein 4 antibody; Rnf4 antibody; RNF4_HUMAN antibody; SLX5 antibody; Small nuclear ring finger protein antibody; SNURF antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Biotin |
| Immunogen | Recombinant human E3 ubiquitin-protein ligase RNF4 protein (1-103AA) |
| Isotype | IgG |
| Target | RNF4 |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | P78317 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. |
| Supplier | Cusabio |
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