| Product Name | RTDLDSLRTYTL |
|---|---|
| Description | RTDLDSLRTYTL is a phage library selected high affinity 12-mer peptide with high selectivity for alpha(v) beta(6) integrin (avb6). RTDLDSLRTYTL is a selective inhibitor of RGD dependent ligand binding to avb6 in isolated receptor assays with an IC50 of 20 nM, and also in cell adhesion assays with an IC50 of 50 mM. When tested against avb6 binding to immobilized fibronectin, RTDLDSLRTYTL peptide strongly inhibits the avb6 fibronectin interaction with an IC50 of 100 nM. avb6 is a specific receptor for fibronectin which supports epithelial cell proliferation during wound healing and carcinoma progression. |
| Synonyms | IG-020, IG020, RGD, RTDLDSLRTYTL, alpha(v) beta(6) integrin, avb6, avb6 fibronectin interaction |
| Molecular Weight | 1453.61 Da |
| Target | Integrin receptors |
| Amino Acid Sequence | RTDLDSLRTYTL |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Kraft et al (1999) Definition of an unexpected ligand recognition motif for alphav beta6 integrin. J. Biol. Chem. 274(4) 1979 PMID: 9890954Pameijer et al (2007) Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor. Can. Gene Ther. 14 91 PMID: 17024231 Related areas All peptides >All integrin receptor modulators >All immunology research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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