| Product Name | RW2 |
|---|---|
| Description | RW2 is a short peptide containing repeating arginine (R) and tryptophan (W) residues which has been shown to possess antimicrobial and antifungal activity with low cytotoxicity. The positively charged arginine interacts with the bacterial membrane through electrostatic attraction whereas the non-polar tryptophan residue interacts with the lipid bilayer. These two properties allow RW2 to interact with the bacterial membrane, resulting in membrane destabilization and pore formation and bacterial cell death. RW2 has been shown to have enhanced activity in combination with other antimicrobial agents. |
| Synonyms | AM-151, AM151, H-RWRW-NH2, RW 2, RW2, RWRW, RWRW-NH2, antifungal, antimicrobial, membrane destabilization, pore formation |
| Molecular Weight | 701.8 Da |
| Target | Antibacterials,Antifungals |
| Amino Acid Sequence | RWRW-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store dry, dark and frozen |
| Notes | Modifications: C terminal amide |
| References |
Strøm et al (2002) Antimicrobial activity of short arginine- and tryptophan-rich peptides. J. Pept. Sci. 8(8) 431 PMID: 12212806Liu et al (2007) Length effects in antimicrobial peptides of the (RW)n series. Antimicrob. Agents Chemother. 51(2) 597 PMID: 17145799Mohan et al (2014) Enhanced antimicrobial activity of peptide-cocktails against common bacterial contaminants of ex vivo stored platelets. Clin. Microbiol. Infect. 20(1) O39 PMID: 23926880 Related areas All antimicrobial peptides >All antifungal agents >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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