| Product Name | S1H |
|---|---|
| Description |
S1H is a 16-residue peptide designed as a direct sequence mimetic of the site 1 mini-helix (residues 36-51) of wild-type human growth hormone (hGH). S1H acts as an inhibitor by blocking the interaction of hGH with the human growth hormone receptor (hGHR). S1H mitigates phosphorylation of STAT5 in cells co-treated with hGH, reducing intracellular STAT5 phosphorylation levels to those of untreated controls. S1H can be used as a chemical tool to study the molecular nature of hGH–hGHR interactions. |
| Synonyms | S1H (36-51) |
| Molecular Weight | 2025.29 Da |
| Target | Cytokine receptors |
| Amino Acid Sequence | Ac-YIPKEQKYSFLQNPQT-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal acetyl, C terminal amide |
| References |
Basu et al (2021) A novel peptide antagonist of the human growth hormone receptor. J Biol Chem. 296 100588 PMID: 33774052 Related dataAll peptides >All cytokine receptor modulators >All endocrinology categories > |
| Supplier | Isca Biochemicals Limited |
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