| Product Name | S7 |
|---|---|
| Description | S7 is a peptide identified from a phage display library, which selectively binds to the interleukin-6 receptor (IL-6R) alpha chain (gp80) and inhibits IL-6 mediated events. S7 can inhibit IL-6 induced VEGF-A expression and angiogenesis in different cancer cell lines, and can prevent IL-6 mediated survival signalling and sensitise cervical cancer cells to chemotherapy. S7 is bioavailable in vivo, and can induce apoptopic cell death and suppress IL-6 induced tumour growth in mouse models. |
| Synonyms | Peptide L, pepL, S7 peptide |
| Molecular Weight | 815.02 Da |
| Target | Cytokine receptors |
| Amino Acid Sequence | LSLITRL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Su et al (2005) A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res. 65(11) 4827 PMID: 15930303Figueiredo et al (2020) Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo. Mol. Ther. Methods Clin. Dev. 17 739 PMID: 32346551Figueiredo et al (2021) Reengineering Tumor Microenvironment with Sequential Interleukin Delivery. Bioengineering 8(7) 90 PMID: 34209203 Related dataAll peptides >All cytokine receptor modulators >All cancer research categories >All immunology categories > |
| Supplier | Isca Biochemicals Limited |
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