| Product Name | SAAP 148 |
|---|---|
| Description |
SAAP 148 is a synthetic peptide derived from LL-37 which is more stable to plasma proteases and more effective in eradicating bacteria than the parent peptide. In vitro, SAAP (synthetic antimicrobial and antibiofilm peptide) 148 kills MDR pathogens without inducing resistance, prevents biofilm formation, and eliminates established biofilms and persister cells. A single 4-hour treatment with SAAP 148 completely eradicates acute and established biofilm associated infections with methicillin resistant Staphylococcus aureus and MDR Acinetobacter baumannii from wounded ex vivo human skin and murine skin in vivo |
| Synonyms | P148, SAAP-148 |
| Molecular Weight | 3267.16 Da |
| Target | Antibacterials |
| Amino Acid Sequence | Ac-LKRVWKRVFKLLKRYWRQLKKPVR-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal acetylated, C terminal amidated |
| References |
de Breij et al (2018) The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Science Translational Medicine 10 (423) DOI: 10.1126/scitranslmed.aan4044Scheper et al (2018) SAAP-148 Eradicates MRSA Persisters Within Mature Biofilm Models Simulating Prosthetic Joint Infection. Front Microbiol. 12 625952 PMID: 33584628van Gent et al (2022) Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin. Antibiotics (Basel) 11(5) 673 PMID: 35625317 Related areasAll antimicrobial peptides >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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