| Product Name | SB 3CT |
|---|---|
| Description | SB 3CT is a potent, competitive and non-selective MMP2 inhibitor with a Ki of 28 nM which also inhibits MMP9 to a lesser extent (Ki = 400 nM). SB 3CT is active in vivo, neuroprotective and blood-brain barrier permeable. |
| Synonyms | 292605-14-2, MMP2, MMP9, PI-170 PI170, SB 3CT, neuroprotective |
| Molecular Weight | 306.4 Da |
| Target | Matrix metalloproteases |
| Amino Acid Sequence | 2-[[(4-phenoxyphenyl)sulfonyl]methyl]thiirane |
| Form | White solid |
| Purity | >98% by tlc |
| Cas Number | 292605-14-2 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Kleifeld et al (2001) X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 18 17125 PMID: 11278946Gu et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 25 6401 PMID: 16000631Gooyit et al (2012) Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 3 730 PMID: 23077716 Related areasAll small molecules >All matrix metalloprotease modulators > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
