| Product Name | SBP1 |
|---|---|
| Description | SBP1 is a 23 amino acid fragment of the angiotensin-converting enzyme 2 (ACE2) peptidase domain (PD) α1 helix, a key domain for the interaction of ACE2 with the severe acute respiratory syndrome coronavirus receptor binding domain (SARS-CoV-2-RBD). SBP1 binds to the SARS-CoV-2-RBD with an affinity comparable with the corresponding spike protein of SARS-CoV, and can potentially block the mechanism by which SARS-CoV-2 enters into cells. SBP1 offers an opportunity for therapeutic intervention in COVID-19. |
| Synonyms | ACE2, COVID-19, CV-050, CV050, H-IEEQAKTFLDKFNHEAEDLFYQS-NH2, IEEQAKTFLDKFNHEAEDLFYQS-NH2, SARS-CoV, SARS-CoV-2, SBP1, angiotensin-converting enzyme 2, severe acute respiratory syndrome coronavirus, spike protein |
| Molecular Weight | 2802.05 Da |
| Target | Protein-protein interactions,Angiotensin converting enzyme,Antivirals |
| Amino Acid Sequence | IEEQAKTFLDKFNHEAEDLFYQS-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Zhang et al (2020) The first-in-class peptide binder to the SARS-CoV-2 spike protein. bioRxiv 2020.03.19.999318; doi: https://doi.org/10.1101/2020.03.19.999318Zhang et al (2020) Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD. bioRxiv 2020.03.19.999318; doi: https://doi.org/10.1101/2020.03.19.999318 Related areasAll peptides >All angiotensin converting enzyme modulators >All antivirals > |
| Supplier | Isca Biochemicals Limited |
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