| Product Name | SDC2, 19-144aa, Human, Baculovirus |
|---|---|
| Description | SDC2, also known as syndecan 2, is a conserved family of heparan- and chondroitin-sulfate carrying transmembrane protein. It is a cell membrane proteoglycans that can modulate the activity and dynamics of some growth factor receptors and integrins. It is expressed in hepatic stellate cells (HSCs), a key cell type involved in matrix deposition in liver fibrotic disorders. It has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recombinant human SDC2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Syndecan 2, SDC2, CD362, HSPG, HSPG1, SYND2 |
| Host | Virus |
| Molecular Weight | 56.8kDa (505aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | ADPESRAELT SDKDMYLDNS SIEEASGVYP IDDDDYASAS GSGADEDVES PELTTSRPLP KILLTSAAPK VETTTLNIQN KIPAQTKSPE ETDKEKVHLS DSERKMDPAE EDTNVYTEKH SDSLFKRTEH HHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 0.1M NaCl, and 10% glycerol |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Renga B., et al. (2014) PLoS One. 9:e94798. Essner JJ., et al. (2006) Int J Biochem Cell Biol. 38:152-156. |
| Background | SDC2, also known as syndecan 2, is a conserved family of heparan- and chondroitin-sulfate carrying transmembrane protein. It is a cell membrane proteoglycans that can modulate the activity and dynamics of some growth factor receptors and integrins. It is expressed in hepatic stellate cells (HSCs), a key cell type involved in matrix deposition in liver fibrotic disorders. It has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of the cortical cytoplasm. Recombinant human SDC2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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