| Product Name | SFFLRN-NH2 |
|---|---|
| Description | SFFLRN-NH2 is the tethered ligand domain sequence of murine protease-activated receptor-1 (PAR-1), the G protein-coupled receptor highly expressed in platelets and endothelial cells and one of four protease-activated receptors involved in the regulation of the thrombotic response. SFFLRN-NH2 activates PAR-1 and induces relaxant responses of mouse isolated tracheal smooth muscle preparations which are mediated by prostaglandins. |
| Synonyms | SFLLRN-amide |
| Molecular Weight | 781.9 Da |
| Target | Protease activated receptors |
| Amino Acid Sequence | SFFLRN-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Lan et al (2000) Modulation of airway smooth muscle tone by protease activated receptor-1,-2,-3 and -4 in trachea isolated from infuenza A virus-infected mice. Br. J. Pharmacol. 129 63 PMID: 10694203Lan et al (2001) Role of PGE2 in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea. Br. J. Pharmacol. 132 93 PMID: 11156565 Related data All peptides >All protease activated receptors >All cardiovascular research categories > |
| Supplier | Isca Biochemicals Limited |
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