| Product Name | SHARPIN Antibody, HRP conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against SHARPIN conjugated to HRP |
| Synonyms | DKFZp434N1923 antibody; hSIPL1 antibody; Shank associated RH domain interacting protein antibody; SHANK associated RH domain interactor antibody; Shank interacting protein like 1 antibody; Shank-associated RH domain-interacting protein antibody; Shank-interacting protein-like 1 antibody; Sharpin antibody; SHRPN_HUMAN antibody; SIPL1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP |
| Immunogen | Recombinant Human Sharpin protein (82-171AA) |
| Isotype | IgG |
| Target | SHARPIN |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q9H0F6 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. |
| Supplier | Cusabio |
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