| Product Name | Siah-1/2 Polyclonal Antibody |
|---|---|
| Description | SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.SIAH1 (Siah E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with SIAH1 include Parkinson Disease, Late-Onset. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Innate Immune System. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is SIAH2. SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. SIAH2 (Siah E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Innate Immune System. GO annotations related to this gene include ligase activity and transcription corepressor activity. An important paralog of this gene is SIAH1. |
| Synonyms | SIAH1, HUMSIAH, E3 ubiquitin-protein ligase SIAH1, Seven in absentia homolog 1, Siah-1, Siah-1a, SIAH2, E3 ubiquitin-protein ligase SIAH2, Seven in absentia homolog 2, Siah-2, hSiah2 |
| Host | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human Siah-1/2 |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Uniprot | Q8IUQ4/O43255 |
| Background |
SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.SIAH1 (Siah E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with SIAH1 include Parkinson Disease, Late-Onset. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Innate Immune System. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is SIAH2. SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. SIAH2 (Siah E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Innate Immune System. GO annotations related to this gene include ligase activity and transcription corepressor activity. An important paralog of this gene is SIAH1. |
| Supplier | Elabscience |
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