| Product Name | SIGMAR1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to SIGMAR1 |
| Synonyms | Aging associated gene 8 protein antibody; Aging-associated gene 8 protein antibody; AL024364 antibody; hSigmaR1 antibody; mSigmaR1 antibody; opioid receptor, sigma 1 antibody; opioid receptor, sigma 1 isoform 1 antibody; RP23 167I12.6 antibody; SGMR1_HUMAN antibody; SIG 1R antibody; SIG-1R antibody; Sigma 1-type opioid receptor antibody; Sigma non-opioid intracellular receptor 1 antibody; sigma1 receptor antibody; Sigma1-receptor antibody; Sigma1R antibody; Sigmar1 antibody; SR BP antibody; SR-BP antibody; SR31747 binding protein antibody; SR31747-binding protein antibody; SRBP antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Sigma non-opioid intracellular receptor 1 protein (112-169AA) |
| Isotype | IgG |
| Target | SIGMAR1 |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q99720 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (By similarity). |
| Supplier | Cusabio |
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