| Product Name | Sivelestat |
|---|---|
| Description | Sivelestat, also known as ONO 5046, is a competitive inhibitor of human neutrophil elastase with an IC50 of 0.044 μM. Sivelistat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse but does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin or cathepsin G even at 100μM. Sivelistat is used in the treatment of acute respiratory failure and also improves neuropathic pain. |
| Synonyms | ONO 5046 |
| Molecular Weight | 434.46 Da |
| Target | Serine proteases |
| Amino Acid Sequence | Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid |
| Form | White solid |
| Purity | >95% by HPLC |
| Cas Number | 127373-66-4 |
| Storage | Store dry, dark and frozen |
| References |
Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem. Biophys. Res. Comm. 177(2) 814 PMID: 2049103Weyer and Stucky (2015) Repurposing a leukocyte elastase inhibitor for neuropathic pain. Nat. Med. 21 429 PMID: 25951529 Related areasAll small molecules >All serine protease modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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