| Product Name | SLC3A2, 206-630aa, Human, Baculovirus |
|---|---|
| Description | SLC3A2, also known as 4F2 cell-surface antigen heavy chain isoform c, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. It is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. This protein is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. This protein involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. Recombinant human SLC3A2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | 4F2 cell-surface antigen heavy chain isoform c, SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE |
| Host | Virus |
| Molecular Weight |
66.1kDa (606aa) 70-100KDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | ADPRAPRCRE LPAQKWWHTG ALYRIGDLQA FQGHGAGNLA GLKGRLDYLS SLKVKGLVLG PIHKNQKDDV AQTDLLQIDP NFGSKEDFDS LLQSAKKKSI RVILDLTPNY RGENSWFSTQ VDTVATKVKD ALEFWLQAGV DGFQVRDIEN LKDASSFLAE WQNITKGFSE DRLLIAGTNS SDLQQILSLL ESNKDLLLTS SYLSDSGSTG EHTKSLVTQY LNATGNRWCS WSLSQARLLT SFLPAQLLRL YQLMLFTLPG TPVFSYGDEI GLDAAALPGQ PMEAPVMLWD ESSFPDIPGA VSANMTVKGQ SEDPGSLLSL FRRLSDQRSK ERSLLHGDFH AFSAGPGLFS YIRHWDQNER FLVVLNFGDV GLSAGLQASD LPASASLPAK ADLLLSTQPG REEGSPLELE RLKLEPHEGL LLRFPYAAHH HHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT, 0.1mM PMSF. |
| Concentration | 0.25mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Mastroberardino L., et al. (1998) Nature. 395:288-291. Fort J., et al. (2007) J Biol Chem. 282:31444-31452. |
| Background | SLC3A2, also known as 4F2 cell-surface antigen heavy chain isoform c, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. It is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. This protein is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. This protein involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. Recombinant human SLC3A2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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